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Program

Session 63   Poster Session
Drug-Drug Interactions
4:30-6:30 pm
4E-F

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440-W.
Pharmacokinetic Interaction between Lopinavir/r and Amprenavir in Salvage Therapy
C. Solas*1, A. M. Quinson2, C. Couprie1, I. Ravaux2, I. Poizot-Martin3, A. Durand1, and B. Lacarelle1
1Timone Hosp., 2Conception Hosp., and 3Sainte-Marguerite Hosp., Marseille, France
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441-W. Pharmacokinetics, Efficacy, and Safety of Once-Daily Saquinavir-sgc plus Low-Dose Ritonavir (1200/100 mg) in Combination with Efavirenz in HIV-Pretreated Patients
L. F. López-Cortés, P. Viciana, R. Ruiz-Valderas, R. Contreras, and A. Alarcón*
Hosp. Univ. Virgen del Rocío, Sevilla, Spain
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442-W.
Amprenavir is an Effective Inducer of Delavirdine Metabolism: A Steady-State Pharmacokinetic Interaction Study between Amprenavir and Delavirdine in Healthy Volunteers
U. Justesen*1, N. Klitgaard2, K. Brosen1, and C. Pedersen2
1Univ. of Southern Denmark, Odense and 2Odense Univ. Hosp., Denmark
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443-W. Evaluation of Steady-State Interaction between Atazanavir (ATV) and Efavirenz (EFV)
S. Preston*1, P. Piliero1, E. O'Mara2, V. Mummaneni2, D. Randall2, C. Morvillo1, M. Geraldes2, S. Agarwala2, and G. Drusano1
1Albany Med. Coll., NY and 2Bristol-Myers Squibb Pharamceutical Res. Inst., Princeton, NJ
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444-W. Steady-State Pharmacokinetic Interaction Study of Atazanavir (ATV) with Efavirenz (EFV) and Ritonavir (RTV) in Healthy Subjects
E. O'Mara*1, S. Agarwala1, D. Randall1, M. Geraldes1, R. Stoltz2, and V. Mummaneni1
1Bristol-Myers Squibb Pharmaceutical Res. Inst., Princeton, NJ and 2GFI, Inc., Evansville, IN
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445-W. Pharmacokinetic (PK) Effect of Rifabutin (RIF) on Atazanavir (ATV) with and without Ritonavir (RTV) in Healthy Subjects
S. Agarwala*1, V. Mummaneni1, D. Randall1, M. Geraldes1, R. Stoltz2, and E. O'Mara1
1Bristol-Myers Squibb Pharmaceutical Res. Inst., Princeton, NJ and 2GFI, Inc., Evansville, IN
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446-W.
Pravastatin 40-mg qd Does not Alter Protease Inhibitor (PI) Exposure or Virological Efficacy over 24 Weeks Therapy
G. J. Moyle*1, N. E. Buss2, and B. Gazzard1
1Chelsea and Westminster Hosp., London, UK and 2Roche, Basel, Switzerland
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447-W.
Pharmacokinetics (PK) of Lower Doses of Saquinavir Soft Gel Caps (SQV) (800- and 1200-mg BID) with Itraconazole (Itra) Compared to 1400 mg SQV BID without Itra in HIV-1+ Thai Patients
P. Cardiello*1,2, T. Samor1 , D. Burger3, R. Hoetelmans4, A. Mahanontharit1, K. Ruxrungtham1,5, J. Lange2 , D. A. Cooper6, and P. Phanuphak1
1HIVNET; 2IATEC, Amsterdam;3UMC, Nijmegen, 4Slotervaart Hosp., Amsterdam, The Netherlands; 5Chulalongkorn Univ., Bangkok, Thailand; and 6NCHECR, Univ. of New South Wales, Australia
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448-W.
Nelfinavir Unbound Drug Interactions and Protein Binding Characteristics
F. Aweeka*1, T. Motoya2, L. Thevanayagam1, T. Blaschke3, J. Stone1, A. Jayewardene1, and J. Chi1
1Univ. of California, San Francisco; 2Kagoshima Univ., Japan; and 3Stanford Univ., CA
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